Rhonda Hovan

A focus on the serious issues of pet overpopulation and unwanted puppies has led to the common practice of neutering dogs prior to sexual maturity, often near the age of six months. While this clearly helps reduce unplanned breedings and thereby may serve the public interest, research is increasingly showing that it may not be in the best health interests of an individual dog with a responsible owner. Breeds of dogs vary considerably with regard to their rate of maturity and risk for specific diseases, and the interaction of these factors with natural hormones should properly be taken into consideration when deciding whether and when to neuter a dog. However, appropriately tailoring neutering recommendations to a breed requires awareness of the ways in which neutering and the age of neutering affect specific breeds, and it may be impossible for veterinarians to know this in detail for every breed.

Therefore, below is a review of health consequences to consider when deciding whether and/or when to neuter a Golden Retriever. The term “Golden” will be used when the data are specific to Goldens, and most of this data come from a large breed health survey scientifically conducted and analyzed by a veterinary epidemiologist () The term “dogs” will be used when the data are applicable to many breeds, and supporting references are provided. In some cases the findings have been substantiated across many breeds, but relative risk is also defined specifically for Goldens. The term “neuter” refers to either sex.

Please note that there are both health benefits and detriments associated with neutering and various neutering ages, so decisions will need to balance these complex factors. It is relevant to consider what diseases are more and less common in the breed, and also what diseases have greater or lesser consequences to the dog, so that information is also provided. For example, it is important with reference to cancer risk to know that 18% of all Goldens die from hemangiosarcoma but that testicular cancer is rare (less than ½ of 1%), so that appropriate weight can be given to the effect that neutering has on each of those cancers.

Health Consequences Associated with Neutering and the Age of Neutering

Neutered dogs have a higher incidence of hypothyroidism than do intact dogs. Male Goldens neutered prior to one year of age have an 80% increased risk of hypothyroidism and female Goldens neutered prior to one year of age have a 60% increased risk of hypothyroidism, as compared to those neutered after one year of age or not neutered. Hypothyroidism is a common but treatable disease in the breed.

Neutered dogs have a greater incidence of hip dysplasia and torn cruciate ligaments than intact dogs, and there is some evidence to suggest that this risk is most pronounced in dogs neutered prior to sexual maturity. Hip dysplasia is common in Goldens, and torn cruciate ligaments are less common but not rare. Both of these diseases can be treated surgically, but treatment is costly and success is variable depending on many factors.

There is some evidence that the incidence of cardiac hemangiosarcoma is greatly increased (2-5 times) in neutered dogs, and that the risk of splenic hemangiosarcoma may also be increased in neutered dogs. Hemangiosarcoma is the most common cancer in the breed, causing the death of approximately 1 in 5 Goldens. Most of these tumors occur in the spleen, with fewer but still a substantial number in the heart. This is a rapidly progressing and incurable cancer.

Several studies indicate that the incidence of osteosarcoma (bone cancer) is significantly higher in neutered dogs than in intact dogs, but there is some evidence that this increase is not as great when neutering occurs after sexual maturity. This cancer affects about 5% of Goldens, and is not curable.

Dogs neutered prior to sexual maturity grow taller than their natural genetic potential, and their bone structure is altered toward a more narrow, lanky appearance. Taller Goldens have shorter life spans than shorter Goldens. Among male Goldens, the shortest males live 2.2 years longer than the tallest males; and among female Goldens, the shortest females live 1.1 years longer than the tallest females. It is unlikely that neutering a Golden prior to sexual maturity will alter the dog’s potential height from extremely short to extremely tall, but it will make a noticeable difference in height and thus potentially in life span.

Neutered females have a greatly increased risk of urinary incontinence as compared to those not neutered, but there is some evidence that this increased risk is less significant for dogs neutered after sexual maturity. Urinary incontinence is neither common nor rare in Goldens, and can often (but not always) be treated successfully.

Females neutered prior to their first heat cycle have less than ½ of 1% chance of developing mammary cancer (breast cancer). In females neutered after the first cycle but before the second, this risk increases to 4%. And if a female is not neutered until after her second heat cycle, this risk increases to about 13%. If detected early through regular mammary exams, most but not all mammary cancers can be treated successfully with surgery and sometimes additional therapies.

Males with one or more testicles located in the abdomen (cryptorchidism) are at high risk for testicular cancer and should be neutered prior to 15 months of age, which eliminates this risk. It is not necessary to neuter these dogs prior to sexually maturity to avoid testicular cancer. Testicular cancer is rare (less than ½ of 1%) in dogs with both testicles normally descended into the scrotum.

Females that remain intact are exposed to a significant risk for pyometra (a life threatening uterine infection) that rises with every heat cycle, particularly after the age of five years. Pyometra is a common and rapidly progressing disease in Goldens that must be diagnosed promptly to be successfully treated.

Males that remain intact frequently develop an enlarged prostate gland (benign prostatic hyperplasia) as they age, particularly over the age of seven years. This is not a serious disease, and while it can sometimes be managed medically, neutering affected dogs is curative. This is not to be confused with prostate cancer which is uncommon in the breed, although more common in neutered males than intact males.

Taking all of the above factors into consideration, there is good evidence to support that it is in the best overall health interests of the dog to neuter female Goldens after sexual maturity, at approximately one year of age. This typically allows a female to have one heat cycle but not two, which keeps the risk of mammary cancer low while still providing her with some important health benefits gained by maturing with natural hormones. Of course, the female must be kept on leash or securely fenced away from males for the full three weeks of her heat cycle to avoid unwanted pregnancy, so this should not be undertaken unless the owner is able to be certain that there is no possibility of an accidental breeding.

There are no clear significant health benefits to neutering a normal male, so this decision should be based on factors other than the health of the dog, such as preventing unwanted breedings, reducing the risk of male-to-male dominance/aggression, and reducing roaming behavior and urine marking. If a male is going to be neutered, there is good evidence to support that it is in the overall best health interests of the dog to neuter male Goldens after sexual maturity, at approximately one year of age. Neutering a male after two years of age has less impact on behavior, so if behavioral considerations are important to the owner, neutering should be done prior to the age of two.


Arnold S. Urinary incontinence in castrated bitches. Part I. Significance, clinical aspects and etiopathogenesis. Schweiz Arch Tierheilkd 1997;139:271-276.

Berry SJ, Strandberg JD, Saunders WJ, et al. Development of canine benign prostatic hyperplasia with age. Pros 1986;9:363-373.

Bryan JN, Keeler MR, Henry CJ, et al. A population study of neutering status as a risk factor for canine prostate cancer. Pros 2007;67:1174-1181.

Cooley DM, Beranek BC, Schlittler DL, et al. Endogenous gonadal hormone exposure and bone sarcoma risk. Canc Epidemiol Biomark Prev 2002;11:1434-1440.

Duerr FM, Duncan CG, Savicky RS, et al. Risk factors for excessive tibial plateau angle in large-breed dogs with cranial cruciate ligament disease. J Amer Vet Med Assoc 2007;231:1688-1691.

Egenvall A, Hagman R, Bonnett BN, et al. Breed risk of pyometra in insured dogs in Sweden. J Vet Intern Med 2001;15:530-538.

Hart BL, Eckstein RA. The role of gonadal hormones in the occurrence of objectionable behaviours in dogs and cats. Appl Anim Behav Sci 1997;52:331-344.

Howe LM, Slater MR, Boothe HW, et al. Long-term outcome of gonadectomy performed at an early age or traditional age in dogs. J Amer Vet Med Assoc 2001;218:217-221.

Kustritz MV. Determining the optimal age for gonadectomy of dogs and cats. J Am Vet Med Assoc. 2007 Dec 1;231(11):1665-75.

Nielsen JC, Eckstein RA, Hart BL. Effects of castration on problem behaviors in male dogs with reference to age and duration of behavior. J Amer Vet Med Assoc 1997;211:180-182.

Niskanen M, Thrusfield MV. Associations between age, parity, hormonal therapy and breed, and pyometra in Finnish dogs. Vet Rec 1998;143:493-498.

Panciera DL. Hypothyroidism in dogs: 66 cases (1987-1992). J Amer Vet Med Assoc 1994;204:761-767.

Prymak C, McKee LJ, Goldschmidt MH, et al. Epidemiologic, clinical, pathologic, and prognostic characteristics of splenic hemangiosarcoma and splenic hematoma in dogs: 217 cases (1985). J Amer Vet Med Assoc 1988;193:706-712.

Ru G, Terracini B, Glickman LT, et al. Related risk factors for canine osteosarcoma. Vet J 1998;156:31-39.

Salmeri KR, Bloomberg MS, Scruggs SL, et al. Gonadectomy in immature dogs: effects on skeletal, physical and behavioral development. J Amer Vet Med Assoc 1991;198:1193-1203.

Slauterbeck JR, Pankratz K, Xu KT, et al. Canine ovariohysterectomy and orchiectomy increases the prevalence of ACL injury. Clin Orthop 2004;429:301-305.

Sorenmo K. Canine mammary gland tumors. Vet Clin NA 2003;33:573-596.

Spain CV, Scarlett JM, Houpt KA. Long-term risks and benefits of early-age gonadectomy in dogs. J Amer Vet Med Assoc 2004;224:380-387.

Teske E, Naan EC, VanKijk EM, et al. Canine prostate carcinoma: epidemiological evidence of an increased risk in castrated dogs. Mol Cell Endo 2002;197:251-255.

van Hagen MA, Ducro BJ, van den Broek J, Knol BW. Incidence, risk factors, and heritability estimates of hind limb lameness cause by hip dysplasia in a birth cohort of boxers. Am J Vet Res. 2005 Feb;66(2):307-12.

Verstegen J, Onclin K. Etiopathogeny, classification and prognosis of mammary tumors in the canine and feline species. Proceedings, Society for Theriogenology, 2003:230-238.

Ware WA, Hopper DL. Cardiac tumors in dogs: 1982-1995. J Vet Intern Med 1999;13:95-103.

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